Wrinkle-smoothing hyaluronic acid can now be introduced into the skin without injections, thanks to an Israeli research team that spent years developing a nanotechnology for this purpose.

Facial wrinkles, lines and sagging result from the body’s gradual loss of its ability to produce hyaluronic acid.

In the past, treatments of hyaluronic acid couldn’t get into the skin’s deepest layers except by injection or in a powder form that must be mixed with water and therefore loses its potency.

That problem was solved by a research team headed by Prof. Rachel Lubart and Prof. Aharon Gedanken from the departments of chemistry and physics and Bar-Ilan University’s Institute for Nanotechnology and Advanced Materials (BINA).

The Israeli scientists achieved this breakthrough by micronizing hyaluronic acid.

Based on this development, Israeli cosmeceuticals pioneer Hava Zingboim has created Prophecy, the first-ever cream formula that allows hyaluronic acid to penetrate into the deeper skin layers.

Facial skin before (above) and after treatment with Prophecy hyaluronic acid cream pioneered in Israel. Photo courtesy of Bar-Ilan University

Once they reach nano size, the hyaluronic acid molecules are transferred into the formula, which enables them to remain nano-sized throughout the process.

According to a university statement, this is the only technology in the world capable of creating small molecules that remain small even when applied to the skin.

The effect of the micronized hyaluronic acid applied to the skin is identical to the effect achieved when injecting hyaluronic acid into the skin, with the benefits of enhanced skin texture and a younger look.

Prophecy will be available in Israel shortly for 575 (about $160) per 60 grams (2.11 ounces) and will be marketed globally in September.